Welcome to the Biointerfaces Group of Cornelia G. Palivan!
We study soft bio-hybrid materials resulting from the combination of biomolecules with synthetic assemblies at the nano- and micro-scale. The goal of our research is to probe and understand the relation between the components of bio-hybrid materials as well as the biointerface of such materials with cells or simple animal models. The main questions that guide our research are: How can biomolecules preserve their function in a synthetic environment? How to modify biomolecules to induce new functionality and how is this affected when a bio-hybrid material is designed? How to self-organize bio-hybrid assemblies in more complex architectures to provide multifunctionality? Which are the interactions of bio-hybrid materials with cells? How to produce a new bio-hybrid material with desired functionality for specific applications? Our interest extends from fundamental understanding at the molecular level of such bio-hybrid materials and associated biointerfaces to technological and medical applications.
Immobilization of arrestin-3 on different biosensor platforms for evaluating GPCR binding
S. Yorulmaz Avsar, L.E. Kapinos, C.-A. Schoenenberger, G. F. X Schertler, J. Mühle, B. Meger, R. Y. H. Lim, M. K. Ostermaier, E. Lesca, C. G. Palivan
Phys Chem Chem Phys, 2020.DOI: 10.1039/d0cp01464h.
Bioactive Catalytic Nanocompartments Integrated into Cell Physiology and Their Amplification of a Native Signaling Cascade
A. Belluati, I. Craciun, C. G. Palivan
ACS Nano,2020. DOI: 10.1021/acsnano.0c05574