Welcome to the Biointerfaces Group of Cornelia G. Palivan!
We study soft bio-hybrid materials resulting from the combination of biomolecules with synthetic assemblies at the nano- and micro-scale. The goal of our research is to probe and understand the relation between the components of bio-hybrid materials as well as the biointerface of such materials with cells or simple animal models. The main questions that guide our research are: How can biomolecules preserve their function in a synthetic environment? How to modify biomolecules to induce new functionality and how is this affected when a bio-hybrid material is designed? How to self-organize bio-hybrid assemblies in more complex architectures to provide multifunctionality? Which are the interactions of bio-hybrid materials with cells? How to produce a new bio-hybrid material with desired functionality for specific applications? Our interest extends from fundamental understanding at the molecular level of such bio-hybrid materials and associated biointerfaces to technological and medical applications.
Bioactive Catalytic Nanocompartments Integrated into Cell Physiology and Their Amplification of a Native Signaling Cascade
A. Belluati, I. Craciun, C. G. Palivan
ACS Nano,2020. DOI: 10.1021/acsnano.0c05574
Peptide-Based Nanoassemblies in Gene Therapy and Diagnosis: Paving the Way for Clinical Application
S. Tarvirdipour, X. Huang, V. Mihali, C.-A. Schoenenberger, C. G. Palivan
Molecules, 2020, 25(15), 3482, DOI: 10.3390/molecules25153482
How Can Giant Plasma Membrane Vesicles Serve as a Cellular Model for Controlled Transfer of Nanoparticles?
L. Zartner, M. Garni, I. Craciun, T. Einfalt, C. G. Palivan
Biomacromolecules,2020. DOI: 10.1021/acs.biomac.0c00624
Multicompartment Polymer Vesicles with Artificial Organelles for Signal‐Triggered Cascade Reactions Including Cytoskeleton Formation
A. Belluati, S. Thamboo, A. Najer, V. Maffeis, C. von Planta, I. Craciun, C. G. Palivan, W. Meier
Adv. Funct. Mat., 2020, 2002949, 1-11. DOI: 10.1002/adfm.202002949.
Polymer–Lipid Hybrid Membranes as a Model Platform to Drive Membrane–Cytochrome c Interaction and Peroxidase-like Activity
S. Di Leone, S. Yorulmaz Avsar, A. Belluati, R. P. Wehr, C. G. Palivan, W. Meier
J. Phys. Chem. B, 2020, 124, 4454-4465, DOI: 10.1021/acs.jpcb.0c02727.
Giant Polymer Compartments for Confined Reactions
Elena C. dos Santos , Alessandro Angelini , Dimitri Hürlimann , Wolfgang Meier ,Cornelia G. PalivanChemistry, 2020, DOI:10.3390/chemistry2020028