Welcome to the Biointerfaces Group of Cornelia G. Palivan!

 

We study soft bio-hybrid materials resulting from the combination of biomolecules with synthetic assemblies at the nano- and micro-scale. The goal of our research is to probe and understand the relation between the components of bio-hybrid materials as well as the biointerface of such materials with cells or simple animal models. The main questions that guide our research are: How can biomolecules preserve their function in a synthetic environment? How to modify biomolecules to induce new functionality and how is this affected when a bio-hybrid material is designed? How to self-organize bio-hybrid assemblies in more complex architectures to provide multifunctionality? Which are the interactions of bio-hybrid materials with cells? How to produce a new bio-hybrid material with desired functionality for specific applications? Our interest extends from fundamental understanding at the molecular level of such bio-hybrid materials and associated biointerfaces to technological and medical applications.


Latest Publications

The stability of cell-derived vesicles was improved by anchoring copolymers into their bilayer membrane and subsequent cross-linking. The cross-linked-copolymer vesicles exhibit a remarkable combination of improved properties including significantly reduced membrane permeability, no aggregation in time, enhanced stability and pH-responsiveness. The latter allows loading/releasing of the cargos into/from the cross-linked-copolymer vesicles in a controlled manner that is advantageous for bio-applications.

Cell-derived Vesicles with Increased Stability and On-Demand Functionality by Equipping their Membrane with a Cross-linkable Copolymer
X. Huang, D. Hürlimann, H. T. Spanke, D. Wu, M. Skowicki, I. A. Dinu, E. R. Dufresne, C. G. Palivan
Adv. Healthcare Mater., 2022, DOI: 10.1002/adhm.202202100

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Tailoring Polymer-based Nanoassemblies for Stimuli-Responsive Theranostic Applications
M. S. Muthwill, P. Kong, I. A. Dinu, D. Necula, C. John, C. G. Palivan
Macromol. Biosci.2022, 2200270. DOI: 10.1002/mabi.202200270

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A DNA-Micropatterned Surface for Propagating Biomolecular Signals by Positional on-off Assembly of Catalytic Nanocompartments
V. Maffeis, D. Hürlimann, A. Krywko-Cendrowska, C.-A. Schoenenberger, C. E. Housecroft, C. G. Palivan
Small 2022, DOI: 10.1002/smll.202202818

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Multicomponent Copolymer Planar Membranes with Nanoscale Domain Separation
M. Bina, A. Krywko-Cendrowska, D. Daubian, W. Meier, C. G. Palivan,
Nano Letters, 2022, DOI: 10.1021/acs.nanolett.2c00332

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A self-assembling peptidic platform to boost the cellular uptake and nuclear delivery of oligonucleotides
S.Tarvirdipour,M. Skowicki, C.-A. Schoenenberger, L. E. Kapinos, R. Y. H. Lim, Y. Benenson, C. G. Palivan
Biomater. Sci., 2022, DOI: 10.1039/D2BM00826B

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Current Perspectives on Synthetic Compartments for Biomedical Applications
L. Heuberger, M. Korpidou, O.M. Eggenberger, M. Kyropoulou, C.G. Palivan
Int. J. Mol. Sci.2022, 23, 5718. DOI: 10.3390/ijms23105718

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Tailoring a Solvent-Assisted Method for Solid-Supported Hybrid Lipid−Polymer Membranes
S. Di Leone, M. Kyropoulou, J. Köchlin, R. Wehr, W. P. Meier, C. G. Palivan
Langmuir, 2022, DOI: 10.1021/acs.langmuir.2c00204