Welcome to the Biointerfaces Group of Cornelia G. Palivan!


We study soft bio-hybrid materials resulting from the combination of biomolecules with synthetic assemblies at the nano- and micro-scale. The goal of our research is to probe and understand the relation between the components of bio-hybrid materials as well as the biointerface of such materials with cells or simple animal models. The main questions that guide our research are: How can biomolecules preserve their function in a synthetic environment? How to modify biomolecules to induce new functionality and how is this affected when a bio-hybrid material is designed? How to self-organize bio-hybrid assemblies in more complex architectures to provide multifunctionality? Which are the interactions of bio-hybrid materials with cells? How to produce a new bio-hybrid material with desired functionality for specific applications? Our interest extends from fundamental understanding at the molecular level of such bio-hybrid materials and associated biointerfaces to technological and medical applications.

Latest Publications

Advancing the Design of Artificial Nano-organelles for Targeted Cellular Detoxification of Reactive Oxygen Species
V. Maffeis, M. Skowicki, K. M. P. Wolf, M. Chami, C.-A. Schoenenberger, V. Vogel, C. G. Palivan
Nano Letters 2024, DOI: 10.1021/acs.nanolett.3c03888

Peptide nanocarriers co-delivering an antisense oligonucleotide and photosensitizer elicit synergistic cytotoxicity
S. Tarvirdipour, M. Skowicki, V. Maffeis, S. N. Abdollahi, C.-A. Schoenenberger, C. G. Palivan
J. Colloid Interface Sci. 2024, DOI: 10.1016/j.jcis.2024.03.021


Planar Polymer Membranes Accommodate Functional Self-Assembly of Inserted Resorcinarene Nanocapsules
M.S. Muthwill, M. Bina, N. Paracini, J.P. Coats, S. Merget, S. Yorulmaz Avsar, D. Messmer, K. Tiefenbacher, and C.G. Palivan
ACS Applied Materials & Interfaces 2024, DOI: 10.1021/acsami.3c18687


FAP Targeting of Photosensitizer-Loaded Polymersomes for Increased Light-Activated Cell Killing
M. Skowicki, D. Hürlimann, S. Tarvirdipour, M. Kyropoulou, C.-A. Schoenenberger, S. Gerber-Lemaire, C. G. Palivan
Biomacromolecules 2024, DOI: 10.1021/acs.biomac.3c00943


Microfluidic Giant Polymer Vesicles Equipped with Biopores for High‐Throughput Screening of Bacteria

Heuberger, L.; Messmer, D.; Dos Santos, E. C.; Scherrer, D.; Lörtscher, E.; Schoenenberger, C.; Palivan, C. G. Advanced Science 2023, 2307103. DOI: 10.1002/advs.202307103


Synthetic Cells Revisited: Artificial Cells Construction Using Polymeric Building Blocks
V. Maffeis, L. Heuberger, A. Nikoletić, C.-A. Schoenenberger, C. G. Palivan
Adv. Sci. 2023, 2305837. DOI: 10.1002/advs.202305837


Polymeric Giant Unilamellar Vesicles with Integrated DNA-Origami Nanopores: An Efficient Platform for Tuning Bioreaction Dynamics Through Controlled Molecular Diffusion
R. Cochereau, V. Maffeis, E. C. dos Santos, E. Lörtscher, C. G. Palivan
Advanced Functional Materials, 2023 , p.2304782, DOI: 10.1002/adfm.202304782